Totaly agree with @PatomaS there is not magic bullet to fix this problem. But it would be good to see wireframes or screenshots of your website. What kind of audience are you targeting? One way of making the user read the instructions is to make them interested in the product/service you are providing.
Use of colours and use of "terminal area" http://uxmovement.com/buttons/why-users-click-right-call-to-actions-more-than-left-ones/ ux movement website is down 30/10/12
Also what kind of website is it, why do you need alot of instructions? Take a look at the article by Joel Spolsky: http://www.joelonsoftware.com/uibook/chapters/fog0000000062.html