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Graphical User Interface design (GUI-design for short) refers to the visual aspect of designing computers, appliances, machines, mobile communication devices, software applications, and websites with the focus on the user's experience and interaction. Generally refers to digital rather than physical design.

GUI-design,

user interface design or user interface engineering is the design of computers, appliances, machines, mobile communication devices, software applications, and websites with the focus on the user's experience and interaction. The goal of user interface design is to make the user's interaction as simple and efficient as possible, in terms of accomplishing user goals—what is often called user-centered design.

Reference: Wikipedia, retrieved 2011-04-25

While GUI-design is based on research, information architecture, prototypes, usability considerations, it refers to the design of the graphical user interface, i.e. the look and feel of the actual implementation.

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