I haven’t heard of any study about your question. But I can only base my opinions on readability issues, for this specific case.
For the big paragraph text, is easier to read when aligned to left . It makes it a clear paragraph. Your 3rd option shows the typical “teeth” that annoys the readability. Also not applied in print design for such big amount of text.
For the image, it doesn’t make sense to align it to the left, as it is not a squared image. Since you want to use rounded images, the best is to align those in the center, at equi distance.
As for the title, this choice remains yours, dependent on the content: align it to the center with the image to give more emphasis to the “label” of the image, or align it to the left if to be read together with the paragraph block.
After all, it is all about readability. Inspire your self from print magazines if needed. They figured it out way before the web, and as designers we should not forget that domain.
All the best,