I had a project manager once who insisted that dialog boxes randomize the arrangement of the buttons so that users didn't get in the habit of just clicking through the confirmations. At first, I hated the idea, but after seeing the results, I still do it in new projects, twenty years later.
Unfortunately, just rearranging a few controls is probably inadequate for your need because your users will just become skilled at finding the confirmation button, without ever looking at the settings which need to be checked.
I would suggest that you add a random settings question to the bottom of the screen which must be answered correctly to enable the confirmation button. For example...
If there are twenty settings on the page, you could ask them to enter the value in the fourteenth one. That forces them to look up at the page and figure out which one is the fourteenth. Next time, you could ask for a setting value by name. The trick is to force them to look up at the page and think before proceeding.
Also, if there are any inherent relationships between the settings, they should be validated on every keystroke/mouse click and errors should be highlighted with color. For example, if setting 3 can only be between 1.4 and 1.9 when setting 6 is positive, and if setting 3 is outside that range while setting 6 is positive, both fields should be bright red. Give your users every visible clue possible to make their very boring job easier.