I have groups of content and I can stack them vertically in 100% width rows or horizontally (even-width columns).
Since the user for English language web sites will read left-to-right and the and users don't mind scrolling, one could argue that having vertically stacked content is easier to use:
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However, if one were to stack them horizontally, the user could scan the header text without scrolling in one continuous left to right motion:
Is there compelling evidence that says one approach is better than the other?