I had posted a question earlier asking for views on what would be the ideal background color to enhance readability and had indicated my inclination towards having a dark or a greyish background to make the transition easier. One of the answers made a very interesting point:
The subject matter of the site has a tendency to be potentially depressing - it's important to try to counteract this tendency through aesthetic choices.
Note: The site is about Cancer, so it can be depressing.
So the question here should the color scheme be also determined by the general mood of the content of the site. I would assume the answer is yes but how much should we be concerned about that.