Should you design your laptop computer to have the look and feel of a TV?
As a general rule, a desktop app should look and feel like a desktop app. Many of the design standards and conventions for desktop apps evolved to maximize their usability for the kinds of tasks and conditions these apps are used for, namely heavy and varied input into a fast updating interface. Many web site standards and conventions, in contrast, evolved to maximize their usability for their kinds of tasks and conditions, namely relatively passively viewing of content in a slow updating interface.
The following are some things to avoid that are typical of web sites and web apps:
Over-use of multi-step wizard-like UIs.
Lack of edit-in-place.
Multi-page UIs. Generally multi-window UIs work better for apps.
Excess clutter with minimally relevant controls.
Lack of an object-selection-action model.
Multiple page lists rather than scrolling for large amounts of content.
Lack of scrollable panes within a window (e.g., for tables so the headers stay in view).
Lack of expert support like accelerators, multi-selections, drag-and-drop, pointer tools, context menus, and double-clicking.
However, there are several things about web sites that are worth importing into desktop apps:
Use of variable font and graphics to indicate relative importance and visual hierarchy in form-type UIs.
Links to distinguish controls that merely navigate from command buttons that actually affect the data
In-window error messages which better orient users to the source of the problem than the message boxes typical of desk top apps.
In-window hints and links to provide better contextual help than that from an isolated Help menu item.
Certainly, you can also design for higher screen resolutions in any case. Maybe you even want to borrow the “liquid layout” concept from the web so users can resize their window however is best for them.