Concerning filters in general, I would say that insering a little bar showing the user what filters are on (and where he can delete some) is a great way to give him multiples possibilities to do what he wants.
Also, in your case, I don't think the "apply" bouton is clear enough. I've not even seen it in my first 5 seconds of looking at your design.
I would probably use a "Auto-apply" feature on those filters. The user choose what he wants, the page change accordingly.
This works perfectly if your category are not complex (I mean, if you're working in a environment where you have to choose 10+ filters, auto-apply may not be good, still you should try it out).
Why using Auto-Apply? For the sake of feedback. When a user perform an action, you have to give him real feedback about how his actions are shaping the UI. One example could also be hilighting your "Apply" button when something change and changing the text to "Apply new filters". So the user know that he putted some filters on it.
Hope this will help,