In these kind of situations I always look at what other big players do. In your case there are some huge players.
For example Facebook. Facebook is so huge and widely used, any interaction patterns they have might be considered convention. If you would implement something similar, people would already be familiar with it. Facebook separates friend requests and notifications.
LinkedIn uses the same pattern.
Going with conventions, the answer to your question would be to keep it separated. That is, friend/connection requests from other notifications.
If we look into why Facebook and Linkedin keep these two types of notifications separated is because their entire concept thrives on you having many friends and connections. Friend requests might get lost in the sea of notifications you might get on a daily basis.
You might want to take a look at your concept the same way. Is it important that they interact with these CTA notifications? If yes, keep them separated, so you'll be sure your users won't miss any CTA notifications.
Hope this helps.