When I started my computing carrer in the 1980s the tool we used were very different from those used today. At first there was no possability to even save ones work. You had to write down your code on a piece of paper and the next time you should program retype the whole program from scratch. A few years later, we could save the program on tape.
Later the tape changed to floppy disc where the 3 1/2'' is todays representation to save. But for younger users the floppy does not have a meaning. They might associate a USB memory stick as a more appropriate saving icon.
But for me, changing the icon to a memory stick, would make me confused. Does the icon mean save or save to memory stick. But consider a world were you could choose icon sets depending on which generation you're a part of. It could even be automated as in today digitized world ones computing device is signed in on facebook, twitter, google and other social networks. These networks know much more than your age, so technically it would be possible.
But would it be desireable to have different icon sets depending on which generation you belong to?