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are there some substantial differences between Axure and Omnigraffle Yes. But nothing unsurmountable. Both are wireframing tools. Axure adds interaction design capabilities--though I tend to be cautious in telling people to rely too much on them. I suggest you grab the demo version of Axure and spend a little time with it. I think you'll can get the ...
No. Omnigraffle is more or less a wireframe tool. Axure is a tool for interactive prototypes (you can do wireframes nevertheless). sorry for the bad news.
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