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I am working on wireframes for desktop application, its collaboration system for paramedical staff like chatting and communication stuff.

Now i need to create GUI, Can anyone suggest me that if i make it in photoshop then what would be best practices or can anyone suggest me some other tools for GUI?

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Unfortunately this question is overly broad (best practices for designing a gui in Photoshop) and doesn't specify any particular detail that you may be wanting help with. It also may be covered by some other questions - (although newer tools may be available) – Roger Attrill Oct 20 '12 at 10:11
Roger i have already created wire-frame in mockflow but i need to make GUI, what would be best practice if i make it in Photopshop, its multi platform application and i need present to my client. – Aftab Khalid Oct 20 '12 at 10:24
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@AftabKhalid But "best practice" regarding what? Asking which are the best practices when designing a GUI in Photoshop is like asking NASA what are the important things to think about when you're launching a rocket into space, you can't simply answer a question like that. – AndroidHustle Oct 20 '12 at 13:12
Maybe it is better to clarify the question — what methods to draw desktop GUI design do exist, and which advantages/disadvantages do they have. – Alex Ovtcharenko Oct 20 '12 at 14:27
If you can rephrase the question it will be much better, for instance something in the lines of, what is the most used option to create a GUI if I have to show it to a client? or I'm a designer, how can I create a GUI for my project that the programmers can easily point flaws on it? ... specific questions – PatomaS Oct 22 '12 at 0:32
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closed as not a real question by Roger Attrill, Vitaly Mijiritsky, AndroidHustle, Benny Skogberg, ChrisF Oct 22 '12 at 21:31

It's difficult to tell what is being asked here. This question is ambiguous, vague, incomplete, overly broad, or rhetorical and cannot be reasonably answered in its current form. For help clarifying this question so that it can be reopened, see the FAQ.