Are there any studies of users response to having a sidebar integrated to the main content area (such as facebook) and sidebar outside the content area (such as Google)?

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The sidebar inside the content area is very common, but there has to be a reason Google is opting for that interface (outside content); I've also seen it in other websites recently.
The cons of inside: it might have problems on small screens, and depending on the content more space is not necessarily better... Could having a larger content area such have its drawback compared with a more focused and smalled area?